Olfactory impairment in Parkinson's disease and white matter abnormalities in central olfactory areas: A voxel‐based diffusion tensor imaging study
Identifieur interne : 000614 ( Main/Exploration ); précédent : 000613; suivant : 000615Olfactory impairment in Parkinson's disease and white matter abnormalities in central olfactory areas: A voxel‐based diffusion tensor imaging study
Auteurs : Naroa Ibarretxe-Bilbao [Espagne] ; Carme Junque [Espagne] ; Maria-Jose Marti [Espagne] ; Francesc Valldeoriola [Espagne] ; Pere Vendrell [Espagne] ; Nuria Bargallo [Espagne] ; Mojtaba Zarei [Royaume-Uni] ; Eduardo Tolosa [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
English descriptors
Abstract
Olfactory dysfunction is known to occur before the appearance of the classical motor signs in Parkinson's disease (PD) and diffusion tensor imaging (DTI) studies in PD have reported fractional anisotropy (FA) reductions in the early disease stages. We aimed to investigate the relationship between olfactory dysfunction and white matter (WM) FA of central olfactory areas in early PD. Twenty‐four patients at Hoehn and Yahr stages I and II and 24 healthy controls matched by age, gender and years of education participated in this study. DTI was acquired at a 3 Tesla scanner and odor identification was assessed using the University of Pennsylvania Smell Identification Test (UPSIT). We performed FA voxelwise group comparisons in the central olfactory structures using tract‐based spatial statistics (TBSS) and correlation analyses between FA values in these central olfactory areas and UPSIT scores. Patients with severe microsmia (UPSIT between 19 and 25) and anosmia (UPSIT lower or equal to 18) had lower FA values than PD patients with mild/moderate or no olfactory dysfunction (UPSIT between 26 and 40) and healthy controls in the WM adjacent to gyrus rectus. In addition, patients with anosmia had reduced FA in the WM surrounding primary olfactory areas in comparison with healthy controls. FA values in the WM adjacent to primary olfactory cortex and right gyrus rectus correlated with UPSIT scores in the PD group. This study demonstrates, for the first time, that microstructural WM reductions are present in the central olfactory system of early stage PD patients and that these reductions are associated with reduced ability to smell. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23208
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We aimed to investigate the relationship between olfactory dysfunction and white matter (WM) FA of central olfactory areas in early PD. Twenty‐four patients at Hoehn and Yahr stages I and II and 24 healthy controls matched by age, gender and years of education participated in this study. DTI was acquired at a 3 Tesla scanner and odor identification was assessed using the University of Pennsylvania Smell Identification Test (UPSIT). We performed FA voxelwise group comparisons in the central olfactory structures using tract‐based spatial statistics (TBSS) and correlation analyses between FA values in these central olfactory areas and UPSIT scores. Patients with severe microsmia (UPSIT between 19 and 25) and anosmia (UPSIT lower or equal to 18) had lower FA values than PD patients with mild/moderate or no olfactory dysfunction (UPSIT between 26 and 40) and healthy controls in the WM adjacent to gyrus rectus. In addition, patients with anosmia had reduced FA in the WM surrounding primary olfactory areas in comparison with healthy controls. FA values in the WM adjacent to primary olfactory cortex and right gyrus rectus correlated with UPSIT scores in the PD group. This study demonstrates, for the first time, that microstructural WM reductions are present in the central olfactory system of early stage PD patients and that these reductions are associated with reduced ability to smell. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Oxfordshire</li></region><settlement><li>Barcelone</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Espagne"><noRegion><name sortKey="Ibarretxe Ilbao, Naroa" sort="Ibarretxe Ilbao, Naroa" uniqKey="Ibarretxe Ilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name></noRegion><name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name><name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name><name sortKey="Ibarretxe Ilbao, Naroa" sort="Ibarretxe Ilbao, Naroa" uniqKey="Ibarretxe Ilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name><name sortKey="Ibarretxe Ilbao, Naroa" sort="Ibarretxe Ilbao, Naroa" uniqKey="Ibarretxe Ilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="Maria-Jose" last="Marti">Maria-Jose Marti</name><name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="Maria-Jose" last="Marti">Maria-Jose Marti</name><name sortKey="Marti, Maria Ose" sort="Marti, Maria Ose" uniqKey="Marti M" first="Maria-Jose" last="Marti">Maria-Jose Marti</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><name sortKey="Vendrell, Pere" sort="Vendrell, Pere" uniqKey="Vendrell P" first="Pere" last="Vendrell">Pere Vendrell</name><name sortKey="Vendrell, Pere" sort="Vendrell, Pere" uniqKey="Vendrell P" first="Pere" last="Vendrell">Pere Vendrell</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zarei, Mojtaba" sort="Zarei, Mojtaba" uniqKey="Zarei M" first="Mojtaba" last="Zarei">Mojtaba Zarei</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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